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J Silvio Gutkind Selected Research

Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)

10/2021A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
11/2013Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.
1/2008G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension.
6/2006A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans.
11/2002Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF.
9/2002The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG.

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J Silvio Gutkind Research Topics

Disease

135Neoplasms (Cancer)
01/2022 - 01/2002
71Squamous Cell Carcinoma of Head and Neck
01/2022 - 06/2002
24Carcinogenesis
12/2020 - 09/2002
22Squamous Cell Carcinoma (Epidermoid Carcinoma)
01/2020 - 06/2003
19Neoplasm Metastasis (Metastasis)
01/2021 - 11/2004
16Head and Neck Neoplasms (Head and Neck Cancer)
10/2021 - 09/2007
15Carcinoma (Carcinomatosis)
01/2019 - 11/2002
10Breast Neoplasms (Breast Cancer)
06/2022 - 02/2005
9Mouth Neoplasms (Oral Cancer)
01/2021 - 11/2004
8Uveal melanoma
08/2021 - 01/2013
7Lymphatic Metastasis
01/2016 - 08/2005
7Kaposi Sarcoma (Kaposi's Sarcoma)
01/2010 - 04/2004
5Lung Neoplasms (Lung Cancer)
11/2021 - 04/2005
5Hyperplasia
01/2020 - 12/2004
5Melanoma (Melanoma, Malignant)
11/2019 - 01/2008
5Leukemia
11/2013 - 09/2002
4Wounds and Injuries (Trauma)
01/2019 - 06/2003
4Inflammation (Inflammations)
07/2013 - 02/2005
3Prostatic Neoplasms (Prostate Cancer)
01/2020 - 11/2009
3Colorectal Neoplasms (Colorectal Cancer)
11/2019 - 12/2002
3Colonic Neoplasms (Colon Cancer)
06/2015 - 12/2005
3Hypoxia (Hypoxemia)
03/2009 - 02/2008
2Triple Negative Breast Neoplasms
06/2022 - 01/2016
2Pharyngeal Neoplasms
10/2020 - 04/2016

Drug/Important Bio-Agent (IBA)

27Proteins (Proteins, Gene)FDA Link
10/2021 - 06/2002
21G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
12/2020 - 04/2004
20Sirolimus (Rapamycin)FDA Link
01/2019 - 11/2005
17Biomarkers (Surrogate Marker)IBA
10/2021 - 11/2002
15MTOR InhibitorsIBA
01/2021 - 12/2008
14Pharmaceutical PreparationsIBA
01/2022 - 11/2002
14GTP-Binding Proteins (G-Protein)IBA
12/2020 - 12/2005
11RNA (Ribonucleic Acid)IBA
12/2021 - 06/2002
10Cisplatin (Platino)FDA LinkGeneric
01/2020 - 10/2003
9DNA (Deoxyribonucleic Acid)IBA
12/2021 - 11/2005
9Small Interfering RNA (siRNA)IBA
01/2021 - 06/2006
9TOR Serine-Threonine KinasesIBA
05/2013 - 11/2005
8LigandsIBA
01/2020 - 09/2002
8ErbB Receptors (EGF Receptor)IBA
02/2016 - 06/2003
7Metformin (Glucophage)FDA LinkGeneric
01/2021 - 04/2012
7Phosphotransferases (Kinase)IBA
01/2020 - 04/2003
7EnzymesIBA
07/2012 - 09/2006
7Epidermal Growth Factor (EGF)IBA
12/2010 - 05/2005
6Immune Checkpoint InhibitorsIBA
01/2022 - 12/2017
6Rho Guanine Nucleotide Exchange FactorsIBA
01/2022 - 09/2002
6Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA
10/2021 - 09/2002
6Protein Kinases (Protein Kinase)IBA
10/2021 - 04/2003
6Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2021 - 11/2007
6Biological ProductsIBA
05/2016 - 08/2005
6Carbon Nanotubes (Carbon Nanotube)IBA
05/2014 - 02/2009
6beta CateninIBA
09/2009 - 08/2004
5AntibodiesIBA
01/2022 - 06/2006
5Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
08/2021 - 01/2008
5Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)IBA
12/2020 - 11/2007
5Phosphatidylinositols (Phosphatidylinositol)IBA
01/2020 - 12/2005
5CarcinogensIBA
10/2016 - 08/2005
5CytokinesIBA
02/2015 - 06/2003
5Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
02/2015 - 11/2004
5Interleukin-6 (Interleukin 6)IBA
07/2012 - 06/2003
5Progesterone Receptors (Progesterone Receptor)IBA
05/2012 - 04/2011
5Transforming Growth Factor beta (TGF-beta)IBA
07/2009 - 08/2004
4Monomeric GTP-Binding ProteinsIBA
03/2013 - 11/2004
4ImmunosorbentsIBA
07/2012 - 11/2009
4Progestins (Progestagens)IBA
05/2012 - 04/2011
4Cyclooxygenase 2 (Cyclooxygenase-2)IBA
06/2008 - 12/2002
3Peptides (Polypeptides)IBA
01/2022 - 03/2007
3Estrogen Receptor alphaIBA
01/2022 - 01/2012
3Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
10/2021 - 05/2011
3Protein Isoforms (Isoforms)IBA
10/2021 - 06/2015
3Transcription Factors (Transcription Factor)IBA
01/2021 - 03/2009
3Oncogene Proteins (Oncogene Protein)IBA
01/2020 - 03/2009
3Cetuximab (Erbitux)FDA Link
01/2020 - 09/2014
3AMP-Activated Protein KinasesIBA
01/2019 - 11/2008
3Retinaldehyde (Retinal)IBA
10/2016 - 05/2009
3Semaphorins (Semaphorin)IBA
07/2015 - 09/2002
3ChemokinesIBA
03/2015 - 04/2006
3Heme Oxygenase-1IBA
10/2012 - 11/2007
3ParaffinIBA
10/2012 - 02/2008
3EverolimusFDA Link
05/2012 - 11/2011
3ProgesteroneFDA LinkGeneric
05/2012 - 04/2011
3Hormones (Hormone)IBA
08/2011 - 12/2002
3Complementary DNA (cDNA)IBA
03/2006 - 08/2004
2Focal Adhesion Protein-Tyrosine KinasesIBA
06/2022 - 10/2003
2Immunoconjugates (Immunoconjugate)IBA
01/2022 - 01/2020
2Erlotinib Hydrochloride (CP 358,774)FDA Link
11/2021 - 02/2016
2CollagenIBA
10/2021 - 03/2013
2Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
10/2021 - 05/2005
2Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
10/2021 - 06/2008
2platelet-derived growth factor C (PDGF-C)IBA
01/2021 - 07/2010
2Desmoglein 3IBA
01/2021 - 02/2013
2p38 Mitogen-Activated Protein KinasesIBA
01/2020 - 02/2014
2Matrix Metalloproteinases (MMPs)IBA
01/2020 - 01/2008
2Hypoglycemic Agents (Hypoglycemics)IBA
01/2020 - 03/2015
2Insulin-Like Growth Factor I (IGF-1)IBA
01/2020 - 08/2002

Therapy/Procedure

47Therapeutics
01/2022 - 10/2003
14Immunotherapy
01/2022 - 03/2006
9Drug Therapy (Chemotherapy)
01/2020 - 03/2006
6Radiotherapy
01/2020 - 01/2012
6Lasers (Laser)
05/2014 - 06/2003
4Chemoprevention
10/2012 - 12/2006
3Transplantation
07/2015 - 08/2005